NexION 2000B ICP Mass Spectrometer
PerkinElmer’s NexION® 2000 is the most versatile ICP-MS on the market, featuring an array of unique technologies that combine to deliver the highest performance no matter what your analytical challenge. Discover the effortless versatility of an instrument that makes it easy to handle any sample matrix, any interference, and any particle size.
PerkinElmer received on April 11, 2018 the Application Award from LaborPraxis in the category Bio and Pharma Analysis for the NexION 2000 ICP-MS. We were awarded this prize during analytica 2018 in Munich, Germany, in acknowledgment of a new technique enabling users to quantify the amount of metal in an individual cell for the first time.
Ideal for laboratories testing semiconductors and fine chemicals, the NexION 2000S ICP-MS features:
The NexION 2000 ICP-MS – Triple Quad Power Meets Single Quad Versatility.
| 21 CFR Part 11 Compatible | Yes |
|---|---|
| Depth | 69.0 cm |
| Height | 75.0 cm |
| Model Name | NexION 2000S |
| Portable | No |
| Product Brand Name | NexION |
| Warranty | 1 Year |
| Weight | 150.0 kg |
| Width | 81.0 cm |
Rice represents a dietary staple for over half of the world's population. However, in recent years, concerns have been raised over the presence of high levels of arsenic (As), where this carcinogenic metalloid can be accumulated at levels far exceeding ambient concentrations. Since China is the world's largest producer of rice, the Chinese government released a national standard method in 2014 for food safety – GB 5009.11– to aid the evaluation of As species in rice and rice products. In this document, HPLC-ICP-MS is identified as the preferred analytical technique.
In this study, five arsenic species were characterized in a commercial rice sample and certified reference material using a gradient anion-exchange method in accordance with GB 5009.11. The analysis was performed using a PerkinElmer NexSAR™ HPLC-ICP-MS speciation solution, consisting of a NexSAR inert HPLC coupled to a NexION® ICP-MS.
Concern about air pollution has been growing rapidly, with most of the focus on gaseous pollutants. Airborne particulates, especially small ones, are rapidly gaining attention due to their impact on human health, as smaller particles can be carried over long distances by wind and penetrate deep into the lungs, where contaminants can have direct interaction with lung tissue and the associated blood vessels. Airborne particulates are classified as PM10 for those with aerodynamic diameters less than 10 µm and PM2.5 for those with aerodynamic diameters less than 2.5 µm.
PM2.5 regulations have been implemented throughout the world, and in order to implement a regime to reduce the concentration of PM2.5, it is important to determine the origins of these particulates, hence the need to collect and analyze them.
ICP-MS is often the analytical instrument of choice for such applications due to its low detection limits and wide linear dynamic range. This work describes the collection, sample preparation and inorganic elemental analysis of atmospheric PM10 and PM2.5 using PerkinElmer’s NexION® ICP-MS.
Toxic cyanobacterial blooms were reported worldwide in various aquatic systems, including freshwater rivers, lakes, reservoirs, and eutrophied coastal marine habitats. Cyanobacterial blooms might be caused by a combination of multiple factors, including eutrophication, solar radiation, temperature, current patterns and other associated factors. Their proliferation in aquatic environments can cause death or toxin accumulation in aquatic animals and then, indirectly or directly, affect human health. Microcystis aeruginosa (M. aeruginosa) bloom is the most common harmful algal bloom (HAB) and is widely studied in various fields.
Copper sulfate is an algaecide frequently used for controlling algae growth. The mechanism of copper (Cu)-based algaecide for algal bloom control is not well understood. The amount of Cu required to kill an individual algae cell and the morphology of the cell after being killed is still unknown. Quantification measurement of these phenomena is even more difficult due to the lack of appropriate methodology.
This work demonstrates that single cell (SC)-ICP-MS provides an effective method for the determination of copper algaecide at the cellular level, leveraging the NexION® ICP-MS with Syngistix™ Single Cell Application software module.
With the increasing development of high-tech applications, rare earth elements (REEs) are considered key elements for modern and future industries. Globally, there is growing pressure for analytical solutions that can accurately characterize and quantify REE content in a high-throughput manner to meet the application needs of expanding industries with reliable results to a diverse selection of mineral samples.
This work describes the in situ analysis of certified reference materials in selecting five mineral matrices using the NexION® 2000 ICP-MS coupled to a laser ablation (LA) system to demonstrate the performance capabilities of LA-ICP-MS for quantifying rare earth elements.
Boron (B) is studied for its isotope ratio composition in a range of paleoproxy, geochemical, nuclear, medical, and archeological applications. ICP-MS is recognized as a powerful technique for boron isotope analysis. Quadrupole ICP-MS is versatile and not exclusively dedicated to isotope ratio measurements, therefore the appreciation of its isotope ratio capabilities can bring high-quality isotopic ratio analysis into the reach of laboratories with varied analysis needs.
This application note describes the analysis of boron isotope ratios using a NexION® ICP-MS, demonstrating the instrument’s capabilities to measure at the best possible level of precision.
In the textile industry, the use of titanium dioxide (TiO2) nanoparticles (NPs) is increasing due to their ability to provide UV protection, increase the hydrophilic nature of fabrics, provide antibacterial characteristics, and reduce odors. This work demonstrates the ability of PerkinElmer's NexION® Single Particle ICP-MS with Syngistix™ Nano Application Software Module to both detect and measure TiO2 nanoparticles released from textiles.
Breakfast is an important meal in providing essential nutrients to keep your energy levels up throughout the day. How do we ensure the food and beverages we consume are healthy, nutritious and safe? Following is a collection of application notes highlighting solutions that will help you identify micronutrients in milk, cereal, juice and fresh and dried fruits as well as toxic metals in tea, dairy products and apple juice to ensure safety of your breakfast foods.
Eye drops are commonly used medications which are available both over-the-counter and as prescriptions in various forms. Because eye drops are classified as a parenteral medication and have relatively large daily doses, the inorganic components in eye drops must be present at low concentrations. As a result, ICP-MS is the most appropriate technique for the determination of trace elements in eye drops.
The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. This work discusses the sample preparation and analysis of Class 1, 2, and 3 elements in a variety of eye drops with the NexION ICP-MS, following the criteria defined in ICH Q3D. The developed methodology (both sample preparation and analytical) demonstrates both accuracy and stability.
Owing to the toxicity of heavy metals, it is increasingly important to test cannabis flowers and other cannabis derivatives so that patient and consumer safety is maintained as the use of cannabis becomes more common. This need has translated into an increasing demand for testing cannabis flowers and other cannabis derivatives for toxins such as the heavy metals cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg). In this application note, we present data to illustrate the successful validation of the Titan MPS™ Microwave Sample Preparation System and the NexION® ICP-MS for the determination of heavy metals in cannabis flower according to the validation protocols set in USP General Chapter <233>, which are commonly used for evaluation of the levels of elemental impurities in samples.
Gold nanoparticles (AuNPs) are widely used in industrial and medical applications. They are known to form naturally during the weathering of Au-bearing mineral deposits, as well as the transformation of gold nuggets and particles. In freshwater systems, they bioaccumulate in aquatic organisms, as shown on test fish species such as zebrafish and guppy.
Several techniques are available to determine gold concentrations in samples – however, few methods have been developed to characterize the size fractions of nanoparticulate gold in complex organic materials. This work is a feasibility study to measure AuNPs in complex organic matrices using Single Particle ICP-MS, as may be applied to environmental monitoring or exploration, demonstrating the ability of PerkinElmer’s NexION® ICP-MS Single Particle Analyzer to reliably detect and characterize nanoparticles in soil and aquatic samples.
Single Particle (SP) ICP-MS is an analytical technique that has demonstrated tremendous potential for the measurement and characterization of metal-containing nanoparticles (NPs) in a wide range of sample types, including environmental. One of the most challenging matrices is seawater due to its high salt content, which causes severe difficulties when analyzed for NPs due to matrix suppression and cone clogging.
This work demonstrates the ability of the NexION® ICP-MS, coupled to the dedicated Syngistix™ Nano Application software module, to measure silver (Ag) nanoparticles in seawater and track their transformations over time.
The elemental analysis of soils is of vital importance not only for agriculture, but also from an environmental perspective. Toxic metals enter soil primarily through pollution and can be taken up directly by humans in various manners, potentially causing acute or chronically toxic responses. Therefore, the identification of pollutants and determination of the level of toxic elements present in the soil are important aspects to be considered.
This work demonstrates the ability of the NexION® ICP-MS to easily analyze 21 elements in soil over an extended period of time with outstanding accuracy and stability, delivering a complete solution to addressing the challenges in soil analysis.
Testing for harmful metal(loid)s that may be included in raw materials, processes, paints and additives used in the manufacturing processes of children's toys has been mandated by the regulation EN 71-3. This regulation recommends specific testing methods and maximum allowable concentrations of leachable metals and metalloids such as Al, As, B, Ba, Cd, Co, Cr (III), Cr (VI), Cu, Hg, Mn, Ni, Pb, Sb, Se, Sn, organotin, Sr and Zn in parts of toys, with the exclusion of general packaging materials.
This work shows a method for the measurement of hexavalent chromium in different toy material categories in accordance with method EN 71-3 Category II, leveraging the unique combination and capabilities of the NexSAR™ Inert HPLC coupled to the robust NexION® ICP-MS.
Whether your lab is well established or just starting up, having a single-source partner who can offer turnkey solutions that meet the current regulations is essential to a successful business. For years, we’ve worked with government and contract cannabis laboratories to develop industry-leading methods, technology, and exceptional return on investment. We help drive analytical standards and commit to ensuring your laboratory has maximum uptime. Learn about our various testing methods and applications for cannabis analyses. Let us work with you to build an efficient workflow, so you can focus on growing your business and brand.
Feed milling today is a complex business, and agribusinesses both large and small need to balance the nutritional and safety needs of livestock with availability of raw ingredients and their seasonality and variability. Add to that the valuable supplementation and medication that millers supply, and it’s clear: you’re creating a complete nutritional delivery system, not just a simple mix of grains.
It’s clear, glass has a variety of uses, from practical to technological to decorative. In particular, float glass is widely used in architecture, automotive, transportation, photovoltaic, and solar industries.
For glass testing labs around the world, we offer highly accurate and tailored solutions including instrumentation, accessories, software, and services, to ensure you get the most out of your analysis. Focused and flexible, our technology enables glass manufacturers to determine efficient energy storage and test raw materials for the required properties. We provide industry-trusted solutions that align with the latest glass regulations (EN, ISO, and CIE), improving the flow and productivity of your lab. Download our Interactive Brochure to learn more.
The grain industry is very complex. It’s global, diverse, and can also present analytical challenges. Today’s grain users demand more when it comes to quality, safety, and uniformity. In addition, they seek diverse products with unique characteristics.
PerkinElmer is equipped to help the grain industry in its quest to feed the world – nutritiously and economically. Our testing and analysis solutions encompass the three primary areas required for complete knowledge of grains and their derivatives – composition, functionality, and safety.
Food testing labs like yours are constantly challenged with accurately analyzing samples quickly and efficiently - all while striving to reduce costs due to market forces. Your commitment to ensuring meat and seafood are safe for consumption, as demand increases, is an uphill battle.
Our commitment to you: to provide a range of solutions across multiple technologies, products, and services that meets or exceeds the testing needs of food processors. Our solutions offer more efficiency and increased accuracy and sensitivity for better yields in real time with minimal training.
From instrumentation and software to consumables and reagents to service and support, we are dedicated to providing you with end-to-end solutions that ease your everyday challenges of automation, throughput, service, and time to results.
Unrivaled ppq detection limits. Unparalleled usability. Finally analysts can have the best of both worlds with the NexION® 2000 ICP-MS, featuring an array of unique technologies that combine to deliver the highest performance no matter what your analytical challenge. Discover the effortless versatility of an instrument that makes it easy to handle:
Learn more about the benefits of the groundbreaking NexION 2000 ICP-MS - download the brochure.
The International Conference on Harmonization Guideline for Elemental Impurities Q3D (ICH Q3D) has established maximum permitted daily exposure limits for elemental impurities in pharmaceutical products. In combination with the U.S. Pharmacopeia’s (USP) Chapters <232> and <233> on elemental impurities, they redefined how the pharmaceutical and related supply-chain industries will measure, document, and comply with strict new standards to limit the presence of elemental impurities in drug products.
PerkinElmer provides the tools and processes you need to take control of impurities testing for both drug substances and drug products, providing proven, reliable technology for the identification and quantification of elemental impurities and the accurate measurement of residual solvents in accordance with strict regulatory guidelines.
Download this brochure to learn more.
The science and art of creating and maintaining thriving agricultural ecosystems requires cultivating healthy soil, crops and livestock. The safety and efficacy of agricultural chemicals and their uptake into our food supply requires robust, reliable and effective analytical testing on agrochemicals themselves, through the lifecycle of the food they help to generate. In this case study, we dive into a collaborative laboratory between NutriControl and PerkinElmer to discuss the win-win arrangement from the solutions utilized to the savings realized.
The S20 series is the next generation of high-performance, robust, and agile autosamplers designed specifically for PerkinElmer’s spectroscopy platforms - atomic and molecular. The series is comprised of two autosamplers: the S23 with three racks and the S25 with five racks. They are designed to meet the needs of all types of laboratories requiring:
Atomic spectroscopy is a family of techniques for determining the elemental composition of an analyte by its electromagnetic or mass spectrum. Several analytical techniques are available:
And selecting the most appropriate one is the key to achieving accurate, reliable, real-world results.
This guide provides a basic overview of the most commonly used techniques and the information necessary to help you select the one that best suits your specific needs and applications.
Download this poster for an all-in-one view of how PerkinElmer instrumentation can answer the analytical needs of the solar market. From R&D of nanomaterials and advanced materials to solar cell component testing including aging and defect analysis - our UV/Vis, DSC, TGA, FT-IR and ICP systems help our customers face a range of similar challenges to achieve high product quality and reduce costs.
Our High Throughput System (HTS) is a uniquely designed modular sample introduction that integrates with the NexION® series of ICP-MS and the Avio® series of ICP-OES to dramatically reduce sample-to-sample time, thereby improving sample throughput while maintaining operation simplicity. The HTS maximizes productivity by significantly reducing the time required for the sample uptake, stabilization, and washout.
This valve-driven system is fully integrated with the Syngistix platform, eliminating the need for third-party software. Using a metal-free fluid path, the system quickly delivers the sample to the plasma, providing excellent results. With simple programming and workflow, the NexION ICP-MS and Avio ICP-OES with HTS simplifies method development for high-throughput analyses, allowing you to dramatically increase the number of samples you can analyze per day.
Unlike other ICP-MS systems on the market that utilize conventional 40-MHz or 27-MHz commercially available generators which are typically customized and modified to work with ICP-MS instruments, the NexION® 1000/2000/5000 ICP-MS systems feature a 34-MHz frequency free-running RF generator, which was developed specifically for applications using ICP-MS systems. This state-of-the-art RF generator offers a trouble-free user experience, featuring adjustable power with 1 watt increments from 400 to 1600 watts. The accurate impedance matching of this system allows the plasma to quickly adjust to changing sample matrices, ensuring that sensitivity is maintained.
Learn more about the novel 34-MHz RF generator of the NexION 1000/2000/5000 ICP-MS - download this technical note.
PerkinElmer’s AMS system provides a number of benefits to simplify analysis of high-matrix samples with theNexION family of ICP-MS instruments. By introducing a flow of argon into the spray chamber neck, the aerosol stream is diluted,allowing for more efficient ionization, fewer matrix effects, and less deposition on the interface cones, which results in simplifiedsample preparation and higher quality data.
