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NexION 5000 Multi-Quadrupole ICP Mass Spectrometer

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NexION 5000 Multi-Quadrupole ICP Mass Spectrometer
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NexION 5000 Multi-Quadrupole ICP Mass Spectrometer

The NexION® 5000 multi-quadrupole ICP-MS – the first in its category to boast four quads – is innovatively designed to meet and exceed the demanding requirements of ultra-trace elemental applications. It takes ICP-MS performance beyond traditional triple quad to deliver exceptionally low background equivalent concentrations (<1 ppt, even in hot plasma) and outstanding detection limits, key to ensuring accurate, repeatable results. Plus, the NexION 5000 provides superior interference removal, phenomenal stability and unmatched matrix tolerance.

In addition to boasting four quads, the NexION 5000 is also the proud recipient of three awards: Wiley Analytical Science AwardThe Analytical Scientist Innovation Award, and R&D 100 Award. 

Part Number N8160010

The multi-award-winning NexION 5000 ICP-MS is equipped with a host of new and proprietary technologies which together surpass traditional triple-quad capabilities and redefine your expectations:

  • Four quadrupoles:
    • First: Quadrupole Ion Deflector (Q0) directs ions to the entrance of the first mass filter
    • Second: Transmission Analyzer Quadrupole 1 (Q1, full-sized for <0.7 amu mass resolution), acts as a mass filter or as an ion guide to direct ions to the Quadrupole Universal Cell
    • Third: Quadrupole Universal Cell (Q2), empowered by dynamic bandpass tuning, prevents side reactions with residual gases in the cell
    • Fourth: Transmission Analyzer Quadrupole 2 (Q3, full-sized for <0.7 amu mass resolution), acts as a mass filter or as an ion guide to direct ions to the detector
  • Extended Dynamic Range (EDR) increases linear dynamic range to 1012, allowing to run both high and low concentration analytes in a single analytical run, resulting in fewer re-runs
  • Low maintenance for greater uptime:
    • Triple Cone Interface with patent-pending OmniRing combined with Quadrupole Ion Deflector deliver no maintenance beyond cones​, for continual operation and improved stability
    • 34 MHz free-running RF generator offers trouble-free user experience – the plasma is generated by the unique LumiCoil RF load coil, which is air cooled (does not require water or gas cooling), so maintenance-free, eliminating need to replace plasma load coils
  • External status lighting provides easy visibility of state of analysis, optimizing efficiencies
  • Syngistix for ICP-MS software (v. 3.0 or higher) brings together the power of the triple-quad ion optics with an user-friendly workflow in a contemporary user interface
  • Certified to be able to be upgraded to meet SEMI S2/S8 (emergency button) delivers ease of integration in clean room facilities



Depth 85.0 cm
Height 85.0 cm
Product Brand Name NexION
Weight 191.0 kg
Width 114.0 cm

Application Brief

PM10 and PM2.5 Air Pollution Monitoring and Source Apportionment in Asia Using the NexION ICP-MS 

Concern about air pollution has been growing rapidly, with most of the focus on gaseous pollutants. Airborne particulates, especially small ones, are rapidly gaining attention due to their impact on human health, as smaller particles can be carried over long distances by wind and penetrate deep into the lungs, where contaminants can have direct interaction with lung tissue and the associated blood vessels. Airborne particulates are classified as PM10 for those with aerodynamic diameters less than 10 µm and PM2.5 for those with aerodynamic diameters less than 2.5 µm.

PM2.5 regulations have been implemented throughout the world, and in order to implement a regime to reduce the concentration of PM2.5, it is important to determine the origins of these particulates, hence the need to collect and analyze them.

ICP-MS is often the analytical instrument of choice for such applications due to its low detection limits and wide linear dynamic range. This work describes the collection, sample preparation and inorganic elemental analysis of atmospheric PM10 and PM2.5 using PerkinElmer’s NexION® ICP-MS.


Rapid Ultra-Trace Analysis of Impurities in Ultrapure Water using the NexION 5000 ICP-MS 

Since ultrapure water (UPW) is used throughout the semiconductor industry in a variety of applications, impurities need to be controlled as these will directly impact the quality and overall yield of semiconductor products. ICP-MS is often used to accurately quantify sub-ppt concentrations of impurities due to its ability to provide accurate quantification of elements at low concentrations.

This work demonstrates the fast, ultratrace analysis of elements whose detection limits are often compromised by argon-based interferences in UPW using the NexION 5000 Multi-Quadrupole ICP-MS. The use of hydrogen and a single plasma mode (Cold Plasma) allowed for analysis times as short as 116 seconds per sample to be achieved, supporting the rapid response needs for UPW analysis in semiconductor laboratories.


Ultra-Trace Determination of Non-Metallic Elements in Dilute Nitric Acid Using NexION 5000 ICP-MS 

Nitric acid is widely used throughout the semiconductor and electronics industry. Various purity grades are required depending on the application and the intended use. For this reason, the semiconductor industry has required ever-lower detection of a broad range of impurities, including non-metallic elements, in nitric acid solutions in order to meet manufacturing requirements.

Due to the presence of complex spectral interferences resulting from plasma gases and the sample matrix, low-ppt quantification of non-metallic elements in dilute nitric acid can be challenging using conventional ICP-MS. This issue is easily addressed with an ICP-MS system that not only mass filters the ions before they enter the collision-reaction cell but also controls the reaction in the cell, a feature only available in quadrupole cells. This works describes a mixed-mode method to determine detection limits and background equivalent concentrations of non-metallic impurities in a dilute nitric acid solution leveraging the unique capabilities of the NexION® 5000 Multi-Quadrupole ICP-MS.


Ultra-Trace Quantification of Non-Metals in Sulfuric Acid Solutions using the NexION 5000 ICP-MS under Different Cell Gas Conditions 

As semiconductor manufacturing processes are being performed at increasing micro-levels, the demand for ICP-MS instrumentation capable of analyzing non-metallic elements at ultra-trace concentrations has grown. For these applications, the use of an ICP-MS system with a full-length resolving quadrupole before the collision/reaction cell as well as the capability to control the reaction within the cell can dramatically improve detection limits, allowing the detection and quantification of non-metallic elements at low levels.

This work demonstrates the ability of the NexION® 5000 ICP-MS to determine DLs and BECs of typical non-metal contaminants in sulfuric acid solutions, achieving excellent detection limits thanks to the combination of its multi-quad capabilities and other proprietary technologies.



Application Note

Analysis of Blood Using NexION 5000 ICP-MS 

For many years, inductively coupled plasma mass spectrometry (ICP-MS) has been the tool of choice for the trace analysis of elements like lead (Pb), arsenic (As), mercury (Hg), and copper (Cu) in bodily fluids such as urine, blood, serum and saliva, as well as in tissues.

Blood and serum are two common biological fluids which present challenges for trace metal analysis. Blood is a complex mixture, composed mostly of water, but also contains proteins, glucose, mineral salts, hormones, as well as red and white blood cells. Serum is derived from blood and has a similar composition, although it does not contain red or white blood cells or fibrinogens.

This work demonstrates the ability of PerkinElmer’s NexION® 5000 multi-quadrupole ICP-MS to perform reproducible analyses of blood samples with excellent stability over long sample run times, thanks to its winning combination of reaction and collision capabilities with triple quadrupole technology for spectral interference removal – this design allows for the accurate determination of low and high levels of analytes in a single analytical run.


Analysis of Metallic Impurities in Organic Solvents Used in IC Fabrication with the NexION 5000 ICP-MS 

The most commonly used organic chemicals in integrated circuit (IC) fabrication are isopropyl alcohol (IPA), propylene glycol methyl ether acetate (PGMEA), propylene glycol methyl ether (PGME), and n-methyl pyrrolidone (NMP). These solvents can leave behind organic film residues with metallic and non-metallic contamination on the wafers, so high-purity grades are mandated for advanced semiconductor processes.

This application note describes the analysis of 46 elements in IPA, PGMEA and NMP using the NexION® 5000 Multi-Quadrupole ICP-MS. This platform is the first in its category to boast four quads, delivering exceptionally low background equivalent concentrations and outstanding detection limits, enabling the semiconductor industry to quantify contaminants in acidic, basic, and organic chemicals at extremely low levels.


Analysis of Metallic Impurities in Si Wafers Using Fully Automated VPD-ICP-MS 

Silicon (Si) is the most used semiconductor and is a critical element for producing circuits found in everyday electronics. As more industries utilize semiconductor devices and Si wafers in electronic products and services, there is an increasing demand for Si wafers with minimal impurities due to the ever-growing scale of component integration on a chip. Therefore, it is essential to have a reliable technique in the QC process to identify metallic impurities that may have been introduced during production.

This work demonstrates the coupling of an IAS Expert_PS VPD (vapor phase decomposition) system with the PerkinElmer NexION® 5000 Multi-Quadrupole ICP-MS, providing a fully automated solution for the determination of metallic impurities in Si wafers. This is due to the ICP-MS' sensitivity and its ability to remove spectral inferences when performing trace analysis in combination with a platform that eliminates manual operation and chemical exposure to operators to prevent Si wafer contamination.


Analysis of Samples Rich in Rare Earth Elements Prepared by Lithium Borate Fusion on the NexION 5000 ICP-MS 

Rare earth elements (REEs) have many uses in the advanced technology and electronics that are utilized in automobiles, airplanes, camera lenses, medical devices, televisions, smartphones, and computers, to name a few. With the growing demand for REEs to support technological advancement, the search for larger REE deposits and quality ore material is ongoing. Since raw geological materials that contain REEs are usually only found in low concentrations, it is critical to be able to accurately quantify and detect REEs in the collected geological samples since this determines the viability of new mine sites and can help to expand existing ones.

Among the different analytical techniques available, ICP-MS is ideal to detect low concentration REEs, and appropriate sample preparation before analysis by ICP-MS is crucial to deliver accurate results. This work demonstrates the accurate and highly stable quantification of REEs and other elements of interest in geological samples prepared by lithium borate fusion using the NexION® 5000 multi-quadrupole ICP-MS, delivering outstanding robustness, even for sample types that typically present analytical challenges.


Analysis of Semiconductor-Grade Hydrogen Peroxide Using the NexION 5000 ICP-MS 

Contaminants in chemicals used during manufacturing processes have a direct impact on product yield and reliability of semiconductor devices. Within the whole process of integrated circuit manufacturing, wafers are sent for repeated cleaning using hydrogen peroxide (H2O2). Semiconductor Equipment and Materials International (SEMI) standard for H2O2, SEMI C30-1110 - Specifications for Hydrogen Peroxide SEMI Grade 51, specifies maximum contamination levels of 10 ppt for most trace elements.

In this application note, we describe the analysis of 46 elements in 35% H2O2 using the NexION® 5000 Multi-Quadrupole ICP-MS, which offers the ability within a single analysis to determine non-metallic elements down to ppt levels together with other trace metals down to sub-ppt levels. This capability is critical in the analysis of trace contaminants in H2O2, which is used in multiple stages of the wafer fabrication process.


Characterization of Ultrapure Water Using NexION 5000 ICP-MS 

For decades, the semiconductor industry has been designing new devices that are smaller, faster and consume less power than their predecessors. To maintain this trend, the critical features of these devices must also become smaller and have fewer defects. The small diameter of a chip’s features requires the use of higher purity materials. As a result, all liquid chemicals and solid materials used in semiconductor processes should contain extremely low levels of contaminants.

Ultrapure water (UPW) is one of the most essential chemicals in the production of semiconductor devices and is used extensively for all wet-processing steps, including wafer rinsing and the dilution of compounds used in chemical baths.

This application note describes a method for the characterization of UPW using PerkinElmer's NexION® 5000 multi-quadrupole ICP-MS, demonstrating outstanding analytical performance in terms of detection limits (DLs) and background equivalent concentrations (BECs) thanks to its four quadrupoles and a wide range of other technological advantages.


Determination of Bromine in Ultra-High-Purity Copper using the NexION 5000 ICP-MS 

Copper (Cu) is widely used due to its high electrical and thermal conductivity, strong corrosion resistance, excellent workability and moderate strength. It is one of the few metals used most commonly in its pure form, and ultra-pure copper specifically is the standard material used in the bonding wire of most integrated circuits and the cables for audio devices. However, the presence of impurities, such as bromine (Br), in high-purity copper reduces its electrical and thermal conductivity to varying degrees and is a limiting factor on the material’s quality.

This work demonstrates the ability of the NexION® 5000 Multi-Quadrupole ICP-MS to accurately measure bromine in high-purity copper by removing the copper-based interference on bromine.


Determination of Impurities in Electronic-Grade Hydrochloric Acid with the NexION 5000 ICP-MS 

During the production of semiconductor devices, it is crucial to ensure that the silicon wafers are free of contaminants and impurities. The use of high-purity chemicals during the cleaning process is critical to the semiconductor product’s overall quality and performance. Therefore, it is essential to analyze electronic-grade hydrochloric acid (HCl) and hydrogen peroxide for the presence of trace metal contaminants.

This work demonstrates the extreme power of the NexION® 5000 multi-quadrupole ICP-MS to remove interferences in order to achieve low background equivalent concentrations in electronic-grade hydrochloric acid for all analytes.


Determination of Impurities in Lithium Materials with the NexION 5000 ICP-MS 

The capability to identify the presence of impurities in lithium (Li) battery materials is critical for manufacturers and suppliers to ensure that the performance of the final battery is not compromised. Li salts used in battery production are generally extracted from brines and, subsequently, have high impurity levels, which can impact battery lifetime, stability and efficiency, therefore pushing the need for higher purity in these raw materials.

For the analysis of Li salts, PerkinElmer’s award-winning NexION® 5000 ICP-MS offers outstanding detection limits and interference correction thanks to the combination of its multi-quadrupole technology, true quadrupole Universal Cell and other proprietary features.


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Direct Determination of Trace Rare Earth Impurities in High-Purity Europium Oxide using the NexION 5000 ICP-MS 

Rare earth elements (REEs) exhibit many optical, electrical, and magnetic properties, and therefore play an irreplaceable role in high-tech photoelectromagnetic materials. At present, the widely used color TV phosphors, Ni-H batteries, high-performance magnetic materials, etc. are all examples of rare earth elements in high-tech applications. The application of high-purity REEs is mainly concentrated in luminescent materials as well as high-tech fields of electronic as well as giant magnetostrictive materials.

High-purity europium oxide (Eu2O3) is used to make color powder, energy-saving lamp powder, self-luminous powder, etc., for displays. The high-definition display (HDP) currently being developed and used requires higher purity and particle size, and its demand is also greater. Therefore, high-purity rare earth analysis and detection technology is also facing technological innovation as the application demand increases.

This work demonstrates the direct determination of 14 REEs in high-purity Eu2O3 with the NexION® 5000 Multi-Quadrupole ICP-MS by eliminating matrix-based interferences.


Direct Determination of Trace Rare Earth Impurities in High-Purity Praseodymium Oxide with the NexION 5000 ICP-MS 

Rare earth elements (REEs) are often referred to as "industrial vitamins", as they are used in a variety of traditional industrial fields as well as in new materials. A particularly important application of some REEs, for example high-purity praseodymium oxide (Pr6O11), is their use in optoelectronic communication technology, and as with all REEs in these types of applications, the purity of the material and the ability to detect impurities is vitally important. However, one of the biggest challenges in the analysis of impurities in purified REE compounds, such as Pr6O11, is that the impurities are often present at extremely low concentrations.

This work demonstrates the ability of the NexION® 5000 multi-quadrupole ICP-MS to accurately and directly measure 14 trace REE impurities in high-purity Pr6O11 using a combination of Standard and Mass Shift modes with oxygen and pure ammonia.


Direct Trace-Element Analysis in Cell Culture Media and Raw Materials with the NexION 5000 ICP-MS 

Raw material preparation and formulation is a known source of elemental content and variation in cell culture media. Other sources of trace metal concentrations and variability include the leaching of trace metals from bioreactors, preparation vessels and storage containers. Quality control in cell culture media is essential for reducing variability and ensuring improved production yields.

In this application note, a wide spectrum of elements in cell culture media samples were analyzed with high accuracy and precision using the award-winning NexION® 5000 Multi-Quadrupole ICP-MS, the industry’s first four-quadrupole ICP-MS system. The instrument’s outstanding interference removal capabilities deliver interference-free analysis that in turn leads to extremely low detection limits. Plus, Extended Dynamic Range (EDR) allows for the analysis of both low- and high-concentration elements within a single analytical run, which, coupled with the High Throughput System (HTS), dramatically contribute to the overall accuracy, stability, and improved productivity of the system.


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Measurement of Impurities in High-Purity Copper Concentrate using the NexION 5000 ICP-MS 

Most of the copper (Cu) concentrates produced globally contain some impurities, which can affect the price as copper concentrates containing high levels of impurities are not accepted by some smelters. To permit treatment and to maximize the value of a Cu concentrate, the levels of impurities in the concentrate need to be reduced below the limits set by the smelters and, in some cases, the authorities in the producing and receiving countries.

In order to measure the lowest possible levels of impurities, ICP-MS is required, as it is capable to accurately measure in the parts per trillion (ppt) range. However, to achieve these levels, both polyatomic and doubly charged interferences must be dealt with. This work demonstrates the accurate and reliable quantification of impurities in Cu concentrate using the NexION® 5000 ICP-MS, thanks to the combination of its unique multi-quadrupole capabilities and Universal Cell Technology, proven to be effective at removing spectral interferences.


Ultra-Trace Elemental Analysis in High-Purity Sulfuric Acid 

The production of electronic devices is a complex process that requires the use of ultra-pure chemicals during the manufacturing steps. High-purity-grade sulfuric acid (H2SO4) is generally used for cleaning components and etching all metal and organic impurities on silicon wafers.

Impurities in sulfuric acid, or any other chemicals used in semiconductor fabrication, can critically impact device quality and yield. This work describes the analysis of 52 elements in high-purity sulfuric acid using the NexION® 5000 Multi-Quadrupole ICP-MS, which delivers the outstanding analytical performance required by the semiconductor industry for difficult matrices such as 10% H2SO4.




Multi-Quadrupole ICP-MS – Pushing Limits of Detection to the Next Decimal 

As the limits of detection (LODs) for trace metal analysis are increasingly being pushed to the next decimal, a need exists to meet these new detection requirements without compromising accuracy or precision. Inductively coupled plasma mass spectrometry (ICP-MS) is often the technique of choice for routine applications requiring ultra-trace detection limits.

For a number of elements, spectroscopic interferences can have a significant impact on the ability to achieve low detection limits by traditional ICP-MS systems. In this study, we take a look at multi-quadrupole ICP-MS technology, with a focus on the mechanisms of removing spectral and other interferences to secure the LODs, accuracy, and precision needed for challenging applications.

Read this article to learn more about multi-quadrupole ICP-MS technology and its benefits.


Sigma Analytical Services’ Journey as a Cannabis, Food, and Pharma Startup Laboratory 

Newly regulated industries, such as cannabis, must deal with establishing standardized protocols with the prospect of regulations changing quickly and evolving as the industry expands.

When establishing Sigma Analytical Services Inc. in 2017, a new company in a newly regulated industry with the intent to mainly serve hemp and cannabis customers, Dr. Kaveh Kahen, Chairman and CEO, put his trust in PerkinElmer as an experienced authority in application and method development and validation to help Sigma Analytical Services not just get off the ground, but as reliable experts to return to in the future.


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Comprehensive and Compliant Solutions for Glass Analysis 

It’s clear, glass has a variety of uses, from practical to technological to decorative. In particular, float glass is widely used in architecture, automotive, transportation, photovoltaic, and solar industries.

For glass testing labs around the world, we offer highly accurate and tailored solutions including instrumentation, accessories, software, and services, to ensure you get the most out of your analysis. Focused and flexible, our technology enables glass manufacturers to determine efficient energy storage and test raw materials for the required properties. We provide industry-trusted solutions that align with the latest glass regulations (EN, ISO, and CIE), improving the flow and productivity of your lab. Download our Interactive Brochure to learn more.


In-Depth Battery Component Testing 

As the world moves to embrace renewable energy sources and reduce our global CO2 emissions, it will also be more dependent than ever on better battery technology, powering the demands of industries such as automotive, energy storage, and portable consumer goods like power tools, computers, and phones. We understand that laboratories analyzing battery components need reliable, accurate solutions and services to help them to:

  • Design and develop safer batteries that are resistant to heat and wear
  • Continue to improve on battery performance
  • Increase battery lifespan while reducing weight and mass


NexION 5000 Multi-Quadrupole ICP-MS - Interactive Brochure 

In the fast-paced analytical world, accurate and reproducible results are essential to guaranteeing quality and ensuring safety. What many industries have in common is the need for trace-element analysis with superior interference removal, extremely low detection limits, and outstanding background equivalent concentrations (BECs).

That’s the thinking behind the NexION® 5000, the industry's first multi-quadrupole ICP-MS instrument. This cutting-edge system delivers performance beyond high-resolution ICP-MS and traditional triple quad technology.

Discover the unique benefits of the NexION 5000 ICP-MS. Download the interactive brochure.



Case Study

NutriControl and PerkinElmer Collaborate to Serve-up Agricultural and Nutritional Analyses 

The science and art of creating and maintaining thriving agricultural ecosystems requires cultivating healthy soil, crops and livestock. The safety and efficacy of agricultural chemicals and their uptake into our food supply requires robust, reliable and effective analytical testing on agrochemicals themselves, through the lifecycle of the food they help to generate. In this case study, we dive into a collaborative laboratory between NutriControl and PerkinElmer to discuss the win-win arrangement from the solutions utilized to the savings realized.


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New Developments in Multi-Quadrupole ICP-MS Technology for Challenging Applications 

Laboratories conducting trace-elemental analyses require high-performance instrumentation capable of delivering accurate and reproducible results, even at low concentrations. Find out how recent developments in multi-quadrupole ICP-MS technology address these evolving needs.

  • Advantages: superior interference removal, excellent stability, unmatched matrix tolerance, and low maintenance
  • How this innovative technology will eliminate false-positives in your data, for absolute confidence in your results
  • Key application areas that benefit from multi-quad technology: semiconductor, biomonitoring, and others benefitting from ultra-trace-level detection

Download this ebook to learn how multi-quadrupole technology in the award-winning NexION® 5000 ICP-MS will meet and exceed your lab’s testing requirements.


Palm Oil Analysis. Complete lab solutions from upstream to downstream 

Quality control-monitoring and testing are important in ensuring the quality of palm oil. The quality control parameters are used to judge the quality of palm oil products and it can be monitored and tested to ensure that the palm oil is not deliberately or accidentally adulterated.




NexION 5000 ICP-MS – Innovation Recognized 

Perfect for your most challenging applications, the cutting-edge, multi-award-winning NexION® 5000 Multi-Quadrupole ICP-MS is the industry’s first and only four-quadrupole ICP-MS instrument – taking performance well beyond everyday triple-quad technology. And the scientific community is taking notice, as the NexION 5000 has already garnered three prestigious awards from respected organizations:

  • 2021 R&D 100 Award
  • 2021 Wiley Analytical Sciences Award
  • 2020 The Analytical Scientist Award

Read this flyer to learn more about this award-winning solution.


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Atomic Spectroscopy, A Guide to Selecting the Appropriate Technique and System 

Atomic spectroscopy is a family of techniques for determining the elemental composition of an analyte by its electromagnetic or mass spectrum. Several analytical techniques are available:

  • Atomic absorption (AA): flame and graphite furnace
  • Inductively coupled plasma optical emission spectroscopy (ICP-OES)
  • Inductively coupled plasma mass spectrometry (ICP-MS)

And selecting the most appropriate one is the key to achieving accurate, reliable, real-world results.

This guide provides a basic overview of the most commonly used techniques and the information necessary to help you select the one that best suits your specific needs and applications.


NexION 1000/2000/5000 ICP-MS Consumables & Supplies GuideLook to PerkinElmer for all of your consumables and supplies for your NexION 1000, 2000, or 5000 ICP-MS system.

NexION 5000 ICP-MS Preparing Your LabThis document provides information to assist in preparing your laboratory for the PerkinElmer NexION® 5000 ICP-MS system prior to instrument delivery and installation.



Advanced Solutions for Solar Cells 

Download this poster for an all-in-one view of how PerkinElmer instrumentation can answer the analytical needs of the solar market. From R&D of nanomaterials and advanced materials to solar cell component testing including aging and defect analysis - our UV/Vis, DSC, TGA, FT-IR and ICP systems help our customers face a range of similar challenges to achieve high product quality and reduce costs.


Infographic - Solutions for your Toxicology Lab 

Infographic Poster showing the range of different analytical solutions for Toxicology Labs; from GC and LC, to ICP-MS and UV-Vis. Benchtop and floor standing chromatography, spectroscopy and thermal solutions for everyday robust and reliable analyses.



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Product Note

NexION 5000 Multi-Quadrupole ICP-MS 

The NexION® 5000 is a multi-quadrupole-based ICP-MS instrument engineered to remove the most complex interferences, ideal for multi-element analysis applications requiring ultra-trace-level detection. Download this product note to discover all of its innovative features.


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Regulatory Compliance Certification

Product Certificate - Nexion 5000Product Certificate for the Nexion 5000

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Technical Note

Advantages of a Novel Interface Design for NexION 5000 ICP-MS 

The novel design of the second-generation Triple Cone Interface with patent-pending OmniRing was developed specifically for the NexION® 5000 multi-quadrupole ICP-MS with both sensitivity and stability in mind. It builds on the Triple Cone Interface geometry of the NexION series and provides unique solutions to space-charge effects based on the simple, yet highly effective OmniRing technology. Its design focuses on many attributes of an ideal interface for ICP-MS, most notably improved transmission by reducing the ion current while at the same time providing a controlled acceleration of the ions through the interface without transmitting high energy ions into the downstream ion optics. The result is much improved analyte signal intensities without the cost of elevated background levels, delivering the ability to analyze complex matrices at sub-ppt BECs and with robust plasma conditions. In addition to high sensitivity, it also significantly contributes to the unmatched stability of the NexION 5000 ICP-MS with challenging matrices. This is thanks to three stages of differential pumping and a design that minimizes surfaces prone to sample deposition and ion sputtering, such as those using extraction cones and lenses.


Advantages of a Novel Plasma Generator for the NexION 1000/2000/5000 ICP-MS Systems 

Unlike other ICP-MS systems on the market that utilize conventional 40-MHz or 27-MHz commercially available generators which are typically customized and modified to work with ICP-MS instruments, the NexION® 1000/2000/5000 ICP-MS systems feature a 34-MHz frequency free-running RF generator, which was developed specifically for applications using ICP-MS systems. This state-of-the-art RF generator offers a trouble-free user experience, featuring adjustable power with 1 watt increments from 400 to 1600 watts. The accurate impedance matching of this system allows the plasma to quickly adjust to changing sample matrices, ensuring that sensitivity is maintained.

Learn more about the novel 34-MHz RF generator of the NexION 1000/2000/5000 ICP-MS - download this technical note.


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All Matrix Solution System for NexION ICP-MS Platforms 

PerkinElmer’s AMS system provides a number of benefits to simplify analysis of high-matrix samples with theNexION family of ICP-MS instruments. By introducing a flow of argon into the spray chamber neck, the aerosol stream is diluted,allowing for more efficient ionization, fewer matrix effects, and less deposition on the interface cones, which results in simplifiedsample preparation and higher quality data.


Interferences in ICP-MS: Do we still have to worry about them? 

Interferences will always occur in ICP-MS and need to be dealt with. However, the NexION® 5000 multi-quadrupole ICP-MS with quadrupole Universal Cell is able to effectively and reproducibly remove spectral interferences leading to improved accuracy, repeatability and reproducibility, while solving problems difficult for single-quadrupole or even high-resolution ICP-MS instruments.

Download this technical note to learn more about the superior interference removal capabilities of the NexION 5000 ICP-MS, leveraging the unique combination of multi-quadrupole technology, Universal Cell Technology and other proprietary features.


Novel Interference Removal Opportunities with the NexION 5000 ICP-MS 

The NexION® 5000 ICP-MS, with multi-quadrupole technology and Universal Cell, is able to take full advantage of element reactivity with 100% pure gases by analyzing them as cluster ions at higher masses where no interferences reside, and the background is clean. The Universal Cell, thanks to its quadrupole design in combination with dynamic bandpass tuning, provides the unique ability of controlling desirable reactions, promoting some weak reactions, rejecting interferences, and preventing side reactions from taking place.

Learn more about these capabilities - download this technical note, featuring periodic tables with color-coded elements indicating their reactivity with a specific gas (oxygen, ammonia, methane), especially useful for method development in complicated matrices, effectively predicting spectral interferences and providing a way to prevent them.



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